acid-PEG1-bis-PEG3-BCN (exo)

Specifications:

Chemical Formula: C₅₁H₈₁N₅O₁₈
Molecular Weight: 1052.21
CAS: N/A
Purity: >90%
Physical Form: oil
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC

acid-PEG1-bis-PEG3-BCN (exo) is a heterotrifunctional linker containing two BCN moieties for click chemistry and a carboxylic acid group for amide coupling with amine. The BCN demonstrates high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst with least hydrophobicity among all cyclooctynes.

Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst

High chemoselectivity – azides and BCN groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency

Hydrophilic PEG3 Spacer – reduces aggregation, minimizes steric hindrance, and enhances solubility