Specifications:
Chemical Formula: C17H17NO5
Molecular Weight: 315.32
CAS: 1263166-91-1
Purity: >95%
Physical Form: white solid
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC
BCN-PNP (endo) is a building block to synthesize BCN linkers for click chemistry.
The advent of bioorthogonal chemical biology tools for imaging and tracking of biomolecules (proteins, lipids, glycans) in their native environment is providing unique insights into cellular processes that are not achievable with traditional biochemical or molecular biology tools. However, the use of copper in traditional click labeling chemistry limits its application in chemistry biology research wherein oligonucleotide or polysaccharide involved could be degraded by copper. The advancement of metal-free bioorthogonal cycloaddtions between strain-promoted alkyne, so called cyclooctynes, with azide (SPAAC), tetrazines or nitrones (SPANC) could solve this issue. Among the cyclooctyned invented, bicyclo[6.1.0]nonyne (BCN) featuring Cs symmetry displays excellent cycloaddition reaction kinetics.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and BCN groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency