DBCO-PEG11-oxyamine

Specifications:

Chemical Formula: C₄₅H₆₈N₄O₁₅
Molecular Weight: 905.04
CAS: N/A
Purity: >94%
Physical Form: light yellow oil
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC

DBCO-PEG11-oxyamine is a heterobifunctional linker containing a DBCO moiety for click chemistry and an oxyamine group for oxime ligation. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst.

Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst

High chemoselectivity – azides and DBCO groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency

Hydrophilic PEG11 Spacer – reduces aggregation, minimizes steric hindrance, and drastically enhances solubility