Specifications:
Chemical Formula: C45H50N6O12
Molecular Weight: 866.91
CAS: N/A
Purity: >90%
Physical Form: viscous oil
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC
DBCO-PEG4-hydrazone-NHS is a cleavable heterobifunctional linker containing a DBCO moiety for click chemistry and a NHS activated ester. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and DBCO groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Hydrophilic PEG4 Spacer – reduces aggregation, minimizes steric hindrance, and enhances solubility
Cleavable hydrazone linker – can be cleaved under acidic condition