, ,

DBCO-PEG4-SS-TCO

$200.00$380.00

A cleavable heterobifunctional linker containing a DBCO moiety for click chemistry and a TCO moiety for tetrazine ligation

Available Options:

Specifications:

Chemical Formula: C43H58N4O9S2
Molecular Weight: 839.08
CAS: N/A
Purity: >95%
Physical Form: light yellow oil
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC

DBCO-PEG4-SS-TCO is a cleavable heterobifunctional linker containing a DBCO moiety for click chemistry and a TCO moiety for tetrazine ligation. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst. TCO will react with tetrazines via inverse electron demand Diels-Alder cycloaddition to form a stable dihydropyridazine linkage. The extremely fast kinetics and selectivity enables the conjugation of two low abundance biopolymers in an aqueous and otherwise complex chemical environment. This bioorthogonal reaction possesses excellent selectivity and biocompatibility such that the complimentary partners can react with each other within richly functionalized biological systems, in some cases, living organisms. Thus, tetrazine-TCO ligation has found numerous applications in fluorescent imaging, drug delivery, PET and SPECT imaging, radionuclide therapy, radiochemistry or drug target identification among several others.

Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst

High chemoselectivity – azides and DBCO, TCO and tetrazine groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency

Hydrophilic PEG4 Spacer – reduces aggregation, minimizes steric hindrance, and enhances solubility

Cleavable SS bond – may be reduced with TCEP, DTT and GSH

Shopping Cart
Scroll to Top