Specifications:
Chemical Formula: C28H27N3O6S2
Molecular Weight: 565.66
CAS: 1435934-53-4
Purity: >95%
Physical Form: white foam
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC
DBCO-SS-NHS is a cleavable heterobifunctional linker containing a DBCO moiety for click chemistry and an activated NHS ester. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and DBCO groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Cleavable SS bond – can be reduced by free thiol molecules like DTT or GSH