Specifications:
Chemical Formula: C22H30N2O7
Molecular Weight: 434.48
CAS: N/A
Purity: >90% by HPLC
Physical Form: colorless oil
Solubility: DCM, MeOH, DMF and DMSO
Storage at: -80 oC
Methylcyclopropene-PEG3-aldehyde is a heterobifunctional linker containing a methylcyclopropene moiety for inverse electron demand Diels-Alder cycloaddition reactions and an aldehyde. The methylcyclopropene will react with tetrazine to yield a stable dihydropyridazine linkage.
Biocompatible – click reaction occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
Chemoselective – methylcyclopropenes do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Hydrophilic spacer – PEG3 spacer enhanced solubility in aqueous buffers