Specifications:
Chemical Formula: C12H11NO5
Molecular Weight: 249.22
CAS: 1515861-58-1
Purity: 95% by HPLC
Physical Form: oil
Solubility: DCM, THF, DMF and DMSO
Storage at: -20 oC
Methylpropene-PNP is a intermediate for synthesis of MCP linkers.
The development of metabolic oligosaccharide engineering (MOE) as an important tool to visualize glycoconjugates in vitro and in vivo has significantly advanced glycobiology research during the past decade. In this approach, cells are grown in the presence of non-natural monosaccharides that contain a functional group with a unique reactivity (a chemical reporter), but are nevertheless accepted by the cell’s biosynthetic machinery. a carbamate-linked methylcyclopropene tag that is small enough to be accepted by the cell’s metabolism and at the same time highly reactive in the inverse-electron-demand Diels-Alder reaction (DAinv).
Reference:
Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter, Anne-Katrin Spa.te, Holger Buskamp, Andrea Niederwieser, Verena F. Schart, Andreas Marx, and Valentin Wittmann Bioconjugate Chem. 2014, 25, 147-154