Specifications:
Chemical Formula: C29H46N8O9
Molecular Weight: 650.72
CAS: N/A
Purity: >95% by HPLC
Physical Form: red oil
Solubility: DCM, acetonitrile, DMF and DMSO
Storage at: -20 oC
Methyltetrazine-PEG8-azide is a heterobifunctional linker functionalized with a methyltetrazine moiety for inverse electron demand Diels-Alder cycloaddition reactions and an azide for click chemistry. The tetrazine will react with strained alkenes such as trans-cyclooctene, norbornene and cyclopropene to yield a stable dihydropyridazine linkage.
Biocompatible – click reaction occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
Chemoselective – tetrazines and azides do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Unprecedented kinetics – inverse-electron demand Diels-Alder chemistry is the fastest bioorthogonal ligation available
Hydrophilic spacer – PEG8 spacer enhanced solubility in aqueous buffers