Specifications:
Chemical Formula: C79H122N8O26
Molecular Weight: 1599.85
CAS: N/A
Purity: >90%
Physical Form: oil
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -80 oC
NHS-C5-tris-PEG3-BCN (exo) is a heterotetrafunctional linker containing three BCN moieties for click chemistry and an NHS group for amide coupling with amine. The BCN demonstrates high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst with least hydrophobicity among all cyclooctynes.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and BCN groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Hydrophilic PEG3 Spacer – reduces aggregation, minimizes steric hindrance, and enhances solubility