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PTAD-PEG4-alkyne

$230.00

A heterobifunctional linker containing a PTAD moiety for tyrosine click reaction  and an alkyne group for click chemistry

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Specifications:

Chemical Formula: C23H32N4O9
Molecular Weight: 508.52
CAS: N/A
Purity: >95%
Physical Form: colorless oil
Solubility: MeOH, DMF and DMSO
Storage at:  -20 oC

PTAD-PEG4-alkyne is a heterobifunctional linker containing a PTAD moiety for tyrosine click reaction  and an alkyne group for click chemistry.

4-Phenyl-3H-1,2,4-triazoline-3,5(4H)-diones (PTADs) is a recently reported bioorthogonal probe that is capable of click reactions with tyrosine. Their benefits include but not limited to:

  • Demonstrated selectivity against tyrosine over cysteine and lysine.
  • Chemoselective for the phenolic side chain of tyrosine residues in modification of small molecules, peptides, and proteins
  • Applicable in a wide variety of biologically acceptable aqueous buffers over a broad range of pH without using heavy metal catalysts.
  • The tyrosine click linkage offers better stability than maleimide to temperature, extremes of pH, and exposure to human blood plasma.
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