Specifications:
Chemical Formula: C16H18N2O6
Molecular Weight: 334.32
CAS: 64987-85-5
Purity: >95%
Physical Form: white powder
Solubility: DCM, THF, Acetonitrile, DMF and DMSO
Storage at: 0-4oC
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a non-cleavable and membrane permeable crosslinker. It contains an amine-reactive N -hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds.