Specifications:
Chemical Formula: C34H47N5O10
Molecular Weight: 685.76
CAS: N/A
Purity: >95% by HPLC
Physical Form: white powder
Solubility: THF, DCM, DMF and DMSO
Storage at: -20 oC
TCO-PEG4-hydrazone-Mal is a cleavable heterobifunctional linker functionalized with a TCO moiety for inverse electron demand Diels-Alder cycloaddition reactions and a maleimide moiety for sulfhydryl conjugation.Â
Biocompatible –inverse-electron demand Diels-Alder chemistry occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)
Unprecedented kinetics – inverse-electron demand Diels-Alder chemistry is the fastest bioorthogonal ligation available
Hydrophilic spacer – PEG4 spacer enhances solubility in aqueous buffers
Cleavable hydrazone bond – can be cleaved under acidic condition